The MZ-372 allows up to 19 audio sources to be mixed, muted, and routed to two redundant outputs. The rear panel offers six input channels, each with two sets of RCAs for a total of 12 RCA stereo pairs for connecting a variety of equipment. Channels 2 and 3 also offer a switchable phono preamp for connecting turntables. Additionally, each of the six channel inputs offers a dedicated XLR input that is switchable between mic and line. The two outputs offer a pair of balanced XLR and a pair of unbalanced RCA connectors, while the monitor output and sub output each offer a stereo pair of RCAs.

The front panel features six volume sliders for each input channel. Each channel also offers A/B/C source select and is equipped with a dedicated gain trim and a 3-band EQ. The two main outputs feature independent volume knobs. A single combo XLR-1/4" microphone input features a volume control, two band EQ, and a "Talkover" function for music ducking when using a microphone. The TASCAM MZ-372 ships with a power supply.